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Endocrine Abstracts

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ea0040oc4 | (1) | ESEBEC2016

TERT promoter mutations in pancreatic endocrine tumours are frequent in tumours from patients with hereditary syndromes

Vinagre Joao , Nabais Joana , Pinheiro Jorge , Batista Rui , Oliveira Rui , Goncalves Pedro , Pestana Ana , Reis Marta , Mesquita Barbara , Pinto Vasco , Lyra Joana , Godinho Miguel , Lopes Jose Manuel , Sobrinho-Simoes Manuel , Soares Paula

Objective: One of the hallmarks of cancer is its unlimited replicative potential. Recently, telomerase promoter (TERTp) mutations were presented as novel mechanism for telomerase re-activation/expression. Due to this fact, it was our objective to study pancreatic endocrine tumours (PET) and related cell lines, to determine if TERTp mutations were present.Design: We performed characterization of the TERTp in a series of 55 PETs and three common PET cell l...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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